Renal Cell Cancer Update
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Rini, MD Brian I Rini, MD
Department of Solid Tumor Oncology and Urology
Cleveland Clinic Taussig Cancer Center
Associate Professor of Medicine
CCF/CWRU Lerner College of Medicine
Cleveland, Ohio

 
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Track 1 Development of anti-angiogenic therapeutic agents in renal cell carcinoma (RCC)
Track 2 Phase III trial of interferon with or without bevacizumab as first-line therapy for RCC
Track 3 Efficacy of the multikinase inhibitors (MKIs) sunitinib and sorafenib: Clinical implications of sequencing
Track 4 Bevacizumab-associated hypertension and proteinuria
Track 5 Value of debulking nephrectomy for patients with metastatic disease
Track 6 Treatment with bevacizumab for patients with hypertension or at risk for arterial events

Track 7 Tolerability and side effects of sunitinib and sorafenib
Track 8 Hand-foot syndrome associated with sunitinib and sorafenib
Track 9 Sunitinib-associated thyroid abnormalities
Track 10 ASSURE: Phase III trial of adjuvant sorafenib, sunitinib or placebo for intermediate- or high-risk RCC
Track 11 Rationale for the effectiveness of anti-angiogenic agents in the microscopic versus macroscopic disease setting
Track 12 Surgical resection after treatment with an MKI for metastatic disease
Track 13 Identification of responders versus nonresponders to MKIs
Track 14 Potential mechanism of action of MKIs in RCC
Track 15 Temsirolimus in poor-risk RCC
Track 16 Studies evaluating the combination of bevacizumab and MKIs in RCC
Track 17 Downstaging RCC for potentially curative resection
Track 18 Future clinical research strategies in RCC
Track 19 Systemic treatment of nonclear cell RCC
Track 20 Dose escalation and tumor response to MKIs
     
Figlin, MD
Robert A Figlin, MD
Arthur and Rosalie Kaplan Professor of Oncology
Chair, Division of Medical Oncology and Therapeutics Research
Associate Director of Clinical Research
City of Hope Comprehensive Cancer Center
City of Hope National Medical Center and Beckman Research Institute
Duarte, California
 
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Track 1 Overview of RCC
Track 2 Genetic abnormalities, angiogenesis and the biology of RCC
Track 3 Incorporation of molecular signatures into the UCLA and Memorial staging systems
Track 4 Biologic rationale for the development of novel agents in the treatment of RCC
Track 5 Role of sunitinib and sorafenib in the treatment of good- and intermediate-risk RCC

Track 6 The mTOR inhibitor temsirolimus for intermediate- or poor-prognosis RCC
Track 7 Clinical benefits and side effects of angiogenesis inhibition in RCC
Track 8 Clinical trial data on the anti-VEGF monoclonal antibody bevacizumab in RCC
Track 9 HIF-driven versus VEGF-driven pathways in poor- versus good-risk RCC and the selection of a treatment approach
Track 10 SELECT trial: Identification of molecular markers to predict benefit from interleukin-2
Track 11 Clinical algorithm for the treatment of metastatic RCC
Track 12 Counseling patients about side effects and toxicities with the multikinase and mTOR inhibitors
Track 13 Hand-foot syndrome associated with sunitinib and sorafenib
Track 14 Potential differences in the hand-foot syndrome associated with fluoropyrimidines versus MKIs
Track 15 Combining targeted agents with “vertical and horizontal inhibition” strategies
Track 16 ASSURE (ECOG-E2805): Adjuvant sorafenib, sunitinib or placebo for intermediate- or high-risk RCC
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Track 17 Role of novel targeted agents in the treatment of papillary RCC
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Akins, MD Michael B Atkins, MD
Director of Biologic Therapy and Cutaneous Oncology Programs
Director, Cancer Clinical Trials Office
Associate Director for Clinical Research
Beth Israel Deaconess Cancer Center
Deputy Director, Division of Hematology/Oncology
Beth Israel Deaconess Medical Center
Leader, Renal Cancer Program
Dana-Farber/Harvard Cancer Center
Professor of Medicine
Harvard Medical School
Boston, Massachusetts

 
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Track 1 Recent research developments regarding the biology of RCC
Track 2 Etiologic factors associated with RCC
Track 3 Biology of RCC and development of novel MKIs
Track 4 Development of bevacizumab for RCC
Track 5 Efficacy of the mTOR inhibitor temsirolimus in poor-risk RCC
Track 6 Development of a treatment algorithm for RCC and overcoming resistance to MKIs

Track 7 Selection of patients most likely to benefit from interleukin-2
Track 8 Combination therapy strategies in RCC
Track 9 Identification of clinical predictors of response to therapeutic agents in RCC
Track 10 Sequencing agents in the treatment of RCC
Track 11 Side effects of agents blocking the VEGF pathway
Track 12 Dose and dose escalation strategies with sunitinib and sorafenib
Track 13 Side effects of sunitinib and sorafenib
Track 14 Importance of the initial treatment selection in RCC
Track 15 Selection of patients for treatment with interleukin-2
Track 16 Counseling patients to minimize side effects and optimize therapeutic delivery of novel agents in RCC
Track 17 Temsirolimus-associated side effects and toxicity
Track 18 Safety of MKIs in the treatment of CNS metastases
Track 19 Cytoreductive nephrectomy in patients with RCC
Track 20 Challenges in completing adjuvant trials in RCC
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